COVID-19 in transplant recipients: The Spanish experience.
Identifieur interne : 000682 ( Main/Exploration ); précédent : 000681; suivant : 000683COVID-19 in transplant recipients: The Spanish experience.
Auteurs : Elisabeth Coll [Espagne] ; Mario Fernández-Ruiz [Espagne] ; J Emilio Sánchez-Álvarez [Espagne] ; José R. Martínez-Fernández [Espagne] ; Marta Crespo [Espagne] ; Jorge Gayoso [Espagne] ; Teresa Bada-Bosch [Espagne] ; Federico Oppenheimer [Espagne] ; Francesc Moreso [Espagne] ; María O. L Pez-Oliva [Espagne] ; Edoardo Melilli [Espagne] ; Marisa L. Rodríguez-Ferrero [Espagne] ; Carlos Bravo [Espagne] ; Elena Burgos [Espagne] ; Carme Facundo [Espagne] ; Inmaculada Lorenzo [Espagne] ; Í Igo Ya Ez [Espagne] ; Cristina Galeano [Espagne] ; Ana Roca [Espagne] ; Mercedes Cabello [Espagne] ; Manuel G Mez-Bueno [Espagne] ; M Dolores García-Cosío [Espagne] ; Javier Graus [Espagne] ; Laura Llad [Espagne] ; Alicia De Pablo [Espagne] ; Carmelo Loinaz [Espagne] ; Beatriz Aguado [Espagne] ; Domingo Hernández [Espagne] ; Beatriz Domínguez-Gil [Espagne]Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2021.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Spain.
- epidemiology : COVID-19.
- mortality : COVID-19.
- Female, Hematopoietic Stem Cell Transplantation, Humans, Male, Middle Aged, Organ Transplantation, SARS-CoV-2, Transplant Recipients.
Abstract
We report the nationwide experience with solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients diagnosed with coronavirus disease 2019 (COVID-19) in Spain until 13 July 2020. We compiled information for 778 (423 kidney, 113 HSCT, 110 liver, 69 heart, 54 lung, 8 pancreas, 1 multivisceral) recipients. Median age at diagnosis was 61 years (interquartile range [IQR]: 52-70), and 66% were male. The incidence of COVID-19 in SOT recipients was two-fold higher compared to the Spanish general population. The median interval from transplantation was 59 months (IQR: 18-131). Infection was hospital-acquired in 13% of cases. No donor-derived COVID-19 was suspected. Most patients (89%) were admitted to the hospital. Therapies included hydroxychloroquine (84%), azithromycin (53%), protease inhibitors (37%), and interferon-β (5%), whereas immunomodulation was based on corticosteroids (41%) and tocilizumab (21%). Adjustment of immunosuppression was performed in 85% of patients. At the time of analysis, complete follow-up was available from 652 patients. Acute respiratory distress syndrome occurred in 35% of patients. Ultimately, 174 (27%) patients died. In univariate analysis, risk factors for death were lung transplantation (odds ratio [OR]: 2.5; 95% CI: 1.4-4.6), age >60 years (OR: 3.7; 95% CI: 2.5-5.5), and hospital-acquired COVID-19 (OR: 3.0; 95% CI: 1.9-4.9).
DOI: 10.1111/ajt.16369
PubMed: 33098200
Affiliations:
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Martínez-Fernández</name><affiliation wicri:level="3"><nlm:affiliation>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Crespo, Marta" sort="Crespo, Marta" uniqKey="Crespo M" first="Marta" last="Crespo">Marta Crespo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, Hospital del Mar, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Transplant Working Group of the Spanish Society of Nephrology (SEN), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Transplant Working Group of the Spanish Society of Nephrology (SEN), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>REDinREN (RD16/0009/0013), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>REDinREN (RD16/0009/0013), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Gayoso, Jorge" sort="Gayoso, Jorge" uniqKey="Gayoso J" first="Jorge" last="Gayoso">Jorge Gayoso</name><affiliation wicri:level="3"><nlm:affiliation>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bada Bosch, Teresa" sort="Bada Bosch, Teresa" uniqKey="Bada Bosch T" first="Teresa" last="Bada-Bosch">Teresa Bada-Bosch</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Oppenheimer, Federico" sort="Oppenheimer, Federico" uniqKey="Oppenheimer F" first="Federico" last="Oppenheimer">Federico Oppenheimer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Moreso, Francesc" sort="Moreso, Francesc" uniqKey="Moreso F" first="Francesc" last="Moreso">Francesc Moreso</name><affiliation wicri:level="3"><nlm:affiliation>Kidney Transplant Unit, Department of Nephrology, Hospital Universitario Vall d´Hebrón, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Kidney Transplant Unit, Department of Nephrology, Hospital Universitario Vall d´Hebrón, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="L Pez Oliva, Maria O" sort="L Pez Oliva, Maria O" uniqKey="L Pez Oliva M" first="María O" last="L Pez-Oliva">María O. L Pez-Oliva</name><affiliation wicri:level="3"><nlm:affiliation>Department oof Nephrology, Hospital Universitario La Paz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department oof Nephrology, Hospital Universitario La Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Melilli, Edoardo" sort="Melilli, Edoardo" uniqKey="Melilli E" first="Edoardo" last="Melilli">Edoardo Melilli</name><affiliation wicri:level="3"><nlm:affiliation>Kidney Transplant Unit, Department of Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Kidney Transplant Unit, Department of Nephrology, Hospital Universitario de Bellvitge, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rodriguez Ferrero, Marisa L" sort="Rodriguez Ferrero, Marisa L" uniqKey="Rodriguez Ferrero M" first="Marisa L" last="Rodríguez-Ferrero">Marisa L. Rodríguez-Ferrero</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bravo, Carlos" sort="Bravo, Carlos" uniqKey="Bravo C" first="Carlos" last="Bravo">Carlos Bravo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pulmonology, Lung transplant Unit, Hospital Universitario Vall d´Hebrón, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pulmonology, Lung transplant Unit, Hospital Universitario Vall d´Hebrón, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Burgos, Elena" sort="Burgos, Elena" uniqKey="Burgos E" first="Elena" last="Burgos">Elena Burgos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Hospital Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Germans Trias i Pujol, Badalona</wicri:regionArea><wicri:noRegion>Badalona</wicri:noRegion></affiliation></author><author><name sortKey="Facundo, Carme" sort="Facundo, Carme" uniqKey="Facundo C" first="Carme" last="Facundo">Carme Facundo</name><affiliation wicri:level="3"><nlm:affiliation>Kidney Transplant Unit, Fundación Puigvert, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Kidney Transplant Unit, Fundación Puigvert, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lorenzo, Inmaculada" sort="Lorenzo, Inmaculada" uniqKey="Lorenzo I" first="Inmaculada" last="Lorenzo">Inmaculada Lorenzo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Complejo Hospitalario Universitario de Albacete, Albacete</wicri:regionArea><wicri:noRegion>Albacete</wicri:noRegion></affiliation></author><author><name sortKey="Ya Ez, I Igo" sort="Ya Ez, I Igo" uniqKey="Ya Ez I" first="Í Igo" last="Ya Ez">Í Igo Ya Ez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Hospital Universitario de Cruces, Barakaldo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Universitario de Cruces, Barakaldo</wicri:regionArea><wicri:noRegion>Barakaldo</wicri:noRegion></affiliation></author><author><name sortKey="Galeano, Cristina" sort="Galeano, Cristina" uniqKey="Galeano C" first="Cristina" last="Galeano">Cristina Galeano</name><affiliation wicri:level="3"><nlm:affiliation>Kidney Transplant Unit, Hospital Universitario Ramón y Cajal, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Kidney Transplant Unit, Hospital Universitario Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Roca, Ana" sort="Roca, Ana" uniqKey="Roca A" first="Ana" last="Roca">Ana Roca</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Complejo Hospitalario Universitario de Toledo, Toledo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Complejo Hospitalario Universitario de Toledo, Toledo</wicri:regionArea><wicri:noRegion>Toledo</wicri:noRegion></affiliation></author><author><name sortKey="Cabello, Mercedes" sort="Cabello, Mercedes" uniqKey="Cabello M" first="Mercedes" last="Cabello">Mercedes Cabello</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Hospital Regional Universitario de Málaga, Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Regional Universitario de Málaga, Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation></author><author><name sortKey="G Mez Bueno, Manuel" sort="G Mez Bueno, Manuel" uniqKey="G Mez Bueno M" first="Manuel" last="G Mez-Bueno">Manuel G Mez-Bueno</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Hospital Universitario Puerta de Hierro, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Cardiology, Hospital Universitario Puerta de Hierro, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Garcia Cosio, M Dolores" sort="Garcia Cosio, M Dolores" uniqKey="Garcia Cosio M" first="M Dolores" last="García-Cosío">M Dolores García-Cosío</name><affiliation wicri:level="3"><nlm:affiliation>Cardiology Service, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cardiology Service, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Centro de Investigación Biomédica en Red Cardiovascular (CIBERCV), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red Cardiovascular (CIBERCV), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Graus, Javier" sort="Graus, Javier" uniqKey="Graus J" first="Javier" last="Graus">Javier Graus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology, Hospital Universitario Ramón y Cajal, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Gastroenterology, Hospital Universitario Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Llad, Laura" sort="Llad, Laura" uniqKey="Llad L" first="Laura" last="Llad">Laura Llad</name><affiliation wicri:level="3"><nlm:affiliation>Liver Transplant Unit, Hospital Universitario de Bellvitge, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Liver Transplant Unit, Hospital Universitario de Bellvitge, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="De Pablo, Alicia" sort="De Pablo, Alicia" uniqKey="De Pablo A" first="Alicia" last="De Pablo">Alicia De Pablo</name><affiliation wicri:level="3"><nlm:affiliation>Lung Transplant Unit, Department of Pneumology, Hospital Universitario 12 de Octubre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Lung Transplant Unit, Department of Pneumology, Hospital Universitario 12 de Octubre, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Loinaz, Carmelo" sort="Loinaz, Carmelo" uniqKey="Loinaz C" first="Carmelo" last="Loinaz">Carmelo Loinaz</name><affiliation wicri:level="3"><nlm:affiliation>Transplant Unit, Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario 12 de Octubre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Transplant Unit, Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario 12 de Octubre, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Aguado, Beatriz" sort="Aguado, Beatriz" uniqKey="Aguado B" first="Beatriz" last="Aguado">Beatriz Aguado</name><affiliation wicri:level="3"><nlm:affiliation>Transplant Unit. Department of Hematology, Hospital Universitario La Princesa, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Transplant Unit. Department of Hematology, Hospital Universitario La Princesa, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Hernandez, Domingo" sort="Hernandez, Domingo" uniqKey="Hernandez D" first="Domingo" last="Hernández">Domingo Hernández</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Hospital Regional Universitario, Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Regional Universitario, Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Spanish Society of Transplantation (SET), Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Spanish Society of Transplantation (SET), Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Dominguez Gil, Beatriz" sort="Dominguez Gil, Beatriz" uniqKey="Dominguez Gil B" first="Beatriz" last="Domínguez-Gil">Beatriz Domínguez-Gil</name><affiliation wicri:level="3"><nlm:affiliation>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33098200</idno><idno type="pmid">33098200</idno><idno type="doi">10.1111/ajt.16369</idno><idno type="wicri:Area/Main/Corpus">000954</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000954</idno><idno type="wicri:Area/Main/Curation">000954</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000954</idno><idno type="wicri:Area/Main/Exploration">000954</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19 in transplant recipients: The Spanish experience.</title><author><name sortKey="Coll, Elisabeth" sort="Coll, Elisabeth" uniqKey="Coll E" first="Elisabeth" last="Coll">Elisabeth Coll</name><affiliation wicri:level="3"><nlm:affiliation>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Fernandez Ruiz, Mario" sort="Fernandez Ruiz, Mario" uniqKey="Fernandez Ruiz M" first="Mario" last="Fernández-Ruiz">Mario Fernández-Ruiz</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria, Hospital Universitario 12 de Octubre (imas12), President of the Group for the Study of Infection in Transplantation and the Immunocompromised Host (GESITRA-IC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infectious Diseases, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria, Hospital Universitario 12 de Octubre (imas12), President of the Group for the Study of Infection in Transplantation and the Immunocompromised Host (GESITRA-IC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Group for the Study of Infection in Transplantation and the Immunocompromised Host (GESITRA-IC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Group for the Study of Infection in Transplantation and the Immunocompromised Host (GESITRA-IC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Sanchez Lvarez, J Emilio" sort="Sanchez Lvarez, J Emilio" uniqKey="Sanchez Lvarez J" first="J Emilio" last="Sánchez-Álvarez">J Emilio Sánchez-Álvarez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Hospital Universitario de Cabueñes, Gijón, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Universitario de Cabueñes, Gijón</wicri:regionArea><wicri:noRegion>Gijón</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Spanish Society of Nephrology (SEN), Gijón, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Spanish Society of Nephrology (SEN), Gijón</wicri:regionArea><wicri:noRegion>Gijón</wicri:noRegion></affiliation></author><author><name sortKey="Martinez Fernandez, Jose R" sort="Martinez Fernandez, Jose R" uniqKey="Martinez Fernandez J" first="José R" last="Martínez-Fernández">José R. Martínez-Fernández</name><affiliation wicri:level="3"><nlm:affiliation>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Crespo, Marta" sort="Crespo, Marta" uniqKey="Crespo M" first="Marta" last="Crespo">Marta Crespo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, Hospital del Mar, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Transplant Working Group of the Spanish Society of Nephrology (SEN), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Transplant Working Group of the Spanish Society of Nephrology (SEN), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>REDinREN (RD16/0009/0013), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>REDinREN (RD16/0009/0013), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Gayoso, Jorge" sort="Gayoso, Jorge" uniqKey="Gayoso J" first="Jorge" last="Gayoso">Jorge Gayoso</name><affiliation wicri:level="3"><nlm:affiliation>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bada Bosch, Teresa" sort="Bada Bosch, Teresa" uniqKey="Bada Bosch T" first="Teresa" last="Bada-Bosch">Teresa Bada-Bosch</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Oppenheimer, Federico" sort="Oppenheimer, Federico" uniqKey="Oppenheimer F" first="Federico" last="Oppenheimer">Federico Oppenheimer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Moreso, Francesc" sort="Moreso, Francesc" uniqKey="Moreso F" first="Francesc" last="Moreso">Francesc Moreso</name><affiliation wicri:level="3"><nlm:affiliation>Kidney Transplant Unit, Department of Nephrology, Hospital Universitario Vall d´Hebrón, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Kidney Transplant Unit, Department of Nephrology, Hospital Universitario Vall d´Hebrón, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="L Pez Oliva, Maria O" sort="L Pez Oliva, Maria O" uniqKey="L Pez Oliva M" first="María O" last="L Pez-Oliva">María O. L Pez-Oliva</name><affiliation wicri:level="3"><nlm:affiliation>Department oof Nephrology, Hospital Universitario La Paz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department oof Nephrology, Hospital Universitario La Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Melilli, Edoardo" sort="Melilli, Edoardo" uniqKey="Melilli E" first="Edoardo" last="Melilli">Edoardo Melilli</name><affiliation wicri:level="3"><nlm:affiliation>Kidney Transplant Unit, Department of Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Kidney Transplant Unit, Department of Nephrology, Hospital Universitario de Bellvitge, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rodriguez Ferrero, Marisa L" sort="Rodriguez Ferrero, Marisa L" uniqKey="Rodriguez Ferrero M" first="Marisa L" last="Rodríguez-Ferrero">Marisa L. Rodríguez-Ferrero</name><affiliation wicri:level="3"><nlm:affiliation>Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bravo, Carlos" sort="Bravo, Carlos" uniqKey="Bravo C" first="Carlos" last="Bravo">Carlos Bravo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pulmonology, Lung transplant Unit, Hospital Universitario Vall d´Hebrón, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pulmonology, Lung transplant Unit, Hospital Universitario Vall d´Hebrón, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Burgos, Elena" sort="Burgos, Elena" uniqKey="Burgos E" first="Elena" last="Burgos">Elena Burgos</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Hospital Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Germans Trias i Pujol, Badalona</wicri:regionArea><wicri:noRegion>Badalona</wicri:noRegion></affiliation></author><author><name sortKey="Facundo, Carme" sort="Facundo, Carme" uniqKey="Facundo C" first="Carme" last="Facundo">Carme Facundo</name><affiliation wicri:level="3"><nlm:affiliation>Kidney Transplant Unit, Fundación Puigvert, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Kidney Transplant Unit, Fundación Puigvert, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lorenzo, Inmaculada" sort="Lorenzo, Inmaculada" uniqKey="Lorenzo I" first="Inmaculada" last="Lorenzo">Inmaculada Lorenzo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Complejo Hospitalario Universitario de Albacete, Albacete</wicri:regionArea><wicri:noRegion>Albacete</wicri:noRegion></affiliation></author><author><name sortKey="Ya Ez, I Igo" sort="Ya Ez, I Igo" uniqKey="Ya Ez I" first="Í Igo" last="Ya Ez">Í Igo Ya Ez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Hospital Universitario de Cruces, Barakaldo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Universitario de Cruces, Barakaldo</wicri:regionArea><wicri:noRegion>Barakaldo</wicri:noRegion></affiliation></author><author><name sortKey="Galeano, Cristina" sort="Galeano, Cristina" uniqKey="Galeano C" first="Cristina" last="Galeano">Cristina Galeano</name><affiliation wicri:level="3"><nlm:affiliation>Kidney Transplant Unit, Hospital Universitario Ramón y Cajal, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Kidney Transplant Unit, Hospital Universitario Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Roca, Ana" sort="Roca, Ana" uniqKey="Roca A" first="Ana" last="Roca">Ana Roca</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Complejo Hospitalario Universitario de Toledo, Toledo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Complejo Hospitalario Universitario de Toledo, Toledo</wicri:regionArea><wicri:noRegion>Toledo</wicri:noRegion></affiliation></author><author><name sortKey="Cabello, Mercedes" sort="Cabello, Mercedes" uniqKey="Cabello M" first="Mercedes" last="Cabello">Mercedes Cabello</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Hospital Regional Universitario de Málaga, Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Regional Universitario de Málaga, Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation></author><author><name sortKey="G Mez Bueno, Manuel" sort="G Mez Bueno, Manuel" uniqKey="G Mez Bueno M" first="Manuel" last="G Mez-Bueno">Manuel G Mez-Bueno</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Hospital Universitario Puerta de Hierro, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Cardiology, Hospital Universitario Puerta de Hierro, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Garcia Cosio, M Dolores" sort="Garcia Cosio, M Dolores" uniqKey="Garcia Cosio M" first="M Dolores" last="García-Cosío">M Dolores García-Cosío</name><affiliation wicri:level="3"><nlm:affiliation>Cardiology Service, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cardiology Service, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Centro de Investigación Biomédica en Red Cardiovascular (CIBERCV), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red Cardiovascular (CIBERCV), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Graus, Javier" sort="Graus, Javier" uniqKey="Graus J" first="Javier" last="Graus">Javier Graus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology, Hospital Universitario Ramón y Cajal, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Gastroenterology, Hospital Universitario Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Llad, Laura" sort="Llad, Laura" uniqKey="Llad L" first="Laura" last="Llad">Laura Llad</name><affiliation wicri:level="3"><nlm:affiliation>Liver Transplant Unit, Hospital Universitario de Bellvitge, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Liver Transplant Unit, Hospital Universitario de Bellvitge, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="De Pablo, Alicia" sort="De Pablo, Alicia" uniqKey="De Pablo A" first="Alicia" last="De Pablo">Alicia De Pablo</name><affiliation wicri:level="3"><nlm:affiliation>Lung Transplant Unit, Department of Pneumology, Hospital Universitario 12 de Octubre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Lung Transplant Unit, Department of Pneumology, Hospital Universitario 12 de Octubre, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Loinaz, Carmelo" sort="Loinaz, Carmelo" uniqKey="Loinaz C" first="Carmelo" last="Loinaz">Carmelo Loinaz</name><affiliation wicri:level="3"><nlm:affiliation>Transplant Unit, Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario 12 de Octubre, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Transplant Unit, Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario 12 de Octubre, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Aguado, Beatriz" sort="Aguado, Beatriz" uniqKey="Aguado B" first="Beatriz" last="Aguado">Beatriz Aguado</name><affiliation wicri:level="3"><nlm:affiliation>Transplant Unit. Department of Hematology, Hospital Universitario La Princesa, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Transplant Unit. Department of Hematology, Hospital Universitario La Princesa, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Hernandez, Domingo" sort="Hernandez, Domingo" uniqKey="Hernandez D" first="Domingo" last="Hernández">Domingo Hernández</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nephrology, Hospital Regional Universitario, Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Nephrology, Hospital Regional Universitario, Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Spanish Society of Transplantation (SET), Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Spanish Society of Transplantation (SET), Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Dominguez Gil, Beatriz" sort="Dominguez Gil, Beatriz" uniqKey="Dominguez Gil B" first="Beatriz" last="Domínguez-Gil">Beatriz Domínguez-Gil</name><affiliation wicri:level="3"><nlm:affiliation>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>COVID-19 (epidemiology)</term><term>COVID-19 (mortality)</term><term>Female (MeSH)</term><term>Hematopoietic Stem Cell Transplantation (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Organ Transplantation (MeSH)</term><term>SARS-CoV-2 (MeSH)</term><term>Spain (epidemiology)</term><term>Transplant Recipients (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Espagne (épidémiologie)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Receveurs de transplantation (MeSH)</term><term>Transplantation d'organe (MeSH)</term><term>Transplantation de cellules souches hématopoïétiques (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Hematopoietic Stem Cell Transplantation</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Organ Transplantation</term><term>SARS-CoV-2</term><term>Transplant Recipients</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Receveurs de transplantation</term><term>Transplantation d'organe</term><term>Transplantation de cellules souches hématopoïétiques</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report the nationwide experience with solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients diagnosed with coronavirus disease 2019 (COVID-19) in Spain until 13 July 2020. We compiled information for 778 (423 kidney, 113 HSCT, 110 liver, 69 heart, 54 lung, 8 pancreas, 1 multivisceral) recipients. Median age at diagnosis was 61 years (interquartile range [IQR]: 52-70), and 66% were male. The incidence of COVID-19 in SOT recipients was two-fold higher compared to the Spanish general population. The median interval from transplantation was 59 months (IQR: 18-131). Infection was hospital-acquired in 13% of cases. No donor-derived COVID-19 was suspected. Most patients (89%) were admitted to the hospital. Therapies included hydroxychloroquine (84%), azithromycin (53%), protease inhibitors (37%), and interferon-β (5%), whereas immunomodulation was based on corticosteroids (41%) and tocilizumab (21%). Adjustment of immunosuppression was performed in 85% of patients. At the time of analysis, complete follow-up was available from 652 patients. Acute respiratory distress syndrome occurred in 35% of patients. Ultimately, 174 (27%) patients died. In univariate analysis, risk factors for death were lung transplantation (odds ratio [OR]: 2.5; 95% CI: 1.4-4.6), age >60 years (OR: 3.7; 95% CI: 2.5-5.5), and hospital-acquired COVID-19 (OR: 3.0; 95% CI: 1.9-4.9).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">33098200</PMID><DateCompleted><Year>2021</Year><Month>05</Month><Day>13</Day></DateCompleted><DateRevised><Year>2021</Year><Month>05</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>5</Issue><PubDate><Year>2021</Year><Month>05</Month></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am J Transplant</ISOAbbreviation></Journal><ArticleTitle>COVID-19 in transplant recipients: The Spanish experience.</ArticleTitle><Pagination><MedlinePgn>1825-1837</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.16369</ELocationID><Abstract><AbstractText>We report the nationwide experience with solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients diagnosed with coronavirus disease 2019 (COVID-19) in Spain until 13 July 2020. We compiled information for 778 (423 kidney, 113 HSCT, 110 liver, 69 heart, 54 lung, 8 pancreas, 1 multivisceral) recipients. Median age at diagnosis was 61 years (interquartile range [IQR]: 52-70), and 66% were male. The incidence of COVID-19 in SOT recipients was two-fold higher compared to the Spanish general population. The median interval from transplantation was 59 months (IQR: 18-131). Infection was hospital-acquired in 13% of cases. No donor-derived COVID-19 was suspected. Most patients (89%) were admitted to the hospital. Therapies included hydroxychloroquine (84%), azithromycin (53%), protease inhibitors (37%), and interferon-β (5%), whereas immunomodulation was based on corticosteroids (41%) and tocilizumab (21%). Adjustment of immunosuppression was performed in 85% of patients. At the time of analysis, complete follow-up was available from 652 patients. Acute respiratory distress syndrome occurred in 35% of patients. Ultimately, 174 (27%) patients died. In univariate analysis, risk factors for death were lung transplantation (odds ratio [OR]: 2.5; 95% CI: 1.4-4.6), age >60 years (OR: 3.7; 95% CI: 2.5-5.5), and hospital-acquired COVID-19 (OR: 3.0; 95% CI: 1.9-4.9).</AbstractText><CopyrightInformation>© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Coll</LastName><ForeName>Elisabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández-Ruiz</LastName><ForeName>Mario</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-0315-8001</Identifier><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria, Hospital Universitario 12 de Octubre (imas12), President of the Group for the Study of Infection in Transplantation and the Immunocompromised Host (GESITRA-IC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Group for the Study of Infection in Transplantation and the Immunocompromised Host (GESITRA-IC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sánchez-Álvarez</LastName><ForeName>J Emilio</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Department of Nephrology, Hospital Universitario de Cabueñes, Gijón, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Spanish Society of Nephrology (SEN), Gijón, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martínez-Fernández</LastName><ForeName>José R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crespo</LastName><ForeName>Marta</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0001-6992-6379</Identifier><AffiliationInfo><Affiliation>Department of Nephrology, Hospital del Mar, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Transplant Working Group of the Spanish Society of Nephrology (SEN), Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>REDinREN (RD16/0009/0013), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gayoso</LastName><ForeName>Jorge</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bada-Bosch</LastName><ForeName>Teresa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oppenheimer</LastName><ForeName>Federico</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Nephrology, Hospital Clinic, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moreso</LastName><ForeName>Francesc</ForeName><Initials>F</Initials><Identifier Source="ORCID">0000-0002-7267-3963</Identifier><AffiliationInfo><Affiliation>Kidney Transplant Unit, Department of Nephrology, Hospital Universitario Vall d´Hebrón, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López-Oliva</LastName><ForeName>María O</ForeName><Initials>MO</Initials><Identifier Source="ORCID">0000-0003-3503-3518</Identifier><AffiliationInfo><Affiliation>Department oof Nephrology, Hospital Universitario La Paz, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melilli</LastName><ForeName>Edoardo</ForeName><Initials>E</Initials><Identifier Source="ORCID">0000-0001-6965-3745</Identifier><AffiliationInfo><Affiliation>Kidney Transplant Unit, Department of Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez-Ferrero</LastName><ForeName>Marisa L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bravo</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pulmonology, Lung transplant Unit, Hospital Universitario Vall d´Hebrón, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burgos</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Nephrology, Hospital Germans Trias i Pujol, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Facundo</LastName><ForeName>Carme</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Kidney Transplant Unit, Fundación Puigvert, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lorenzo</LastName><ForeName>Inmaculada</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Nephrology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yañez</LastName><ForeName>Íñigo</ForeName><Initials>Í</Initials><AffiliationInfo><Affiliation>Department of Nephrology, Hospital Universitario de Cruces, Barakaldo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galeano</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Kidney Transplant Unit, Hospital Universitario Ramón y Cajal, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roca</LastName><ForeName>Ana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Nephrology, Complejo Hospitalario Universitario de Toledo, Toledo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cabello</LastName><ForeName>Mercedes</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Nephrology, Hospital Regional Universitario de Málaga, Málaga, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gómez-Bueno</LastName><ForeName>Manuel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Hospital Universitario Puerta de Hierro, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-Cosío</LastName><ForeName>MªDolores</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Cardiology Service, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red Cardiovascular (CIBERCV), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Graus</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Hospital Universitario Ramón y Cajal, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lladó</LastName><ForeName>Laura</ForeName><Initials>L</Initials><Identifier Source="ORCID">0000-0002-3717-3306</Identifier><AffiliationInfo><Affiliation>Liver Transplant Unit, Hospital Universitario de Bellvitge, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Pablo</LastName><ForeName>Alicia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Lung Transplant Unit, Department of Pneumology, Hospital Universitario 12 de Octubre, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loinaz</LastName><ForeName>Carmelo</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0002-1873-0568</Identifier><AffiliationInfo><Affiliation>Transplant Unit, Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario 12 de Octubre, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aguado</LastName><ForeName>Beatriz</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Transplant Unit. Department of Hematology, Hospital Universitario La Princesa, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hernández</LastName><ForeName>Domingo</ForeName><Initials>D</Initials><Identifier Source="ORCID">0000-0001-5469-2119</Identifier><AffiliationInfo><Affiliation>Department of Nephrology, Hospital Regional Universitario, Málaga, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Spanish Society of Transplantation (SET), Málaga, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Domínguez-Gil</LastName><ForeName>Beatriz</ForeName><Initials>B</Initials><Identifier Source="ORCID">0000-0002-5695-8993</Identifier><AffiliationInfo><Affiliation>Organización Nacional de Trasplantes (Spanish National Transplant Organization), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Spanish Group for the Study of COVID-19 in Transplant Recipients</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>11</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018380" MajorTopicYN="Y">Hematopoietic Stem Cell Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016377" MajorTopicYN="Y">Organ Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D066027" MajorTopicYN="Y">Transplant Recipients</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">antibiotic: antiviral</Keyword><Keyword MajorTopicYN="Y">clinical decision-making</Keyword><Keyword MajorTopicYN="Y">clinical research/practice</Keyword><Keyword MajorTopicYN="Y">complication: infectious</Keyword><Keyword MajorTopicYN="Y">infection and infectious agents - viral</Keyword><Keyword MajorTopicYN="Y">infectious disease</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>10</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>10</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>10</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>5</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>10</Month><Day>24</Day><Hour>5</Hour><Minute>37</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33098200</ArticleId><ArticleId IdType="doi">10.1111/ajt.16369</ArticleId></ArticleIdList><ReferenceList><Title>REFERENCES</Title><Reference><Citation>Huang C, Wang Y, Li X, et al. 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L Pez-Oliva</name><name sortKey="Llad, Laura" sort="Llad, Laura" uniqKey="Llad L" first="Laura" last="Llad">Laura Llad</name><name sortKey="Loinaz, Carmelo" sort="Loinaz, Carmelo" uniqKey="Loinaz C" first="Carmelo" last="Loinaz">Carmelo Loinaz</name><name sortKey="Lorenzo, Inmaculada" sort="Lorenzo, Inmaculada" uniqKey="Lorenzo I" first="Inmaculada" last="Lorenzo">Inmaculada Lorenzo</name><name sortKey="Martinez Fernandez, Jose R" sort="Martinez Fernandez, Jose R" uniqKey="Martinez Fernandez J" first="José R" last="Martínez-Fernández">José R. Martínez-Fernández</name><name sortKey="Melilli, Edoardo" sort="Melilli, Edoardo" uniqKey="Melilli E" first="Edoardo" last="Melilli">Edoardo Melilli</name><name sortKey="Moreso, Francesc" sort="Moreso, Francesc" uniqKey="Moreso F" first="Francesc" last="Moreso">Francesc Moreso</name><name sortKey="Oppenheimer, Federico" sort="Oppenheimer, Federico" uniqKey="Oppenheimer F" first="Federico" last="Oppenheimer">Federico Oppenheimer</name><name sortKey="Roca, Ana" sort="Roca, Ana" uniqKey="Roca A" first="Ana" last="Roca">Ana Roca</name><name sortKey="Rodriguez Ferrero, Marisa L" sort="Rodriguez Ferrero, Marisa L" uniqKey="Rodriguez Ferrero M" first="Marisa L" last="Rodríguez-Ferrero">Marisa L. Rodríguez-Ferrero</name><name sortKey="Sanchez Lvarez, J Emilio" sort="Sanchez Lvarez, J Emilio" uniqKey="Sanchez Lvarez J" first="J Emilio" last="Sánchez-Álvarez">J Emilio Sánchez-Álvarez</name><name sortKey="Sanchez Lvarez, J Emilio" sort="Sanchez Lvarez, J Emilio" uniqKey="Sanchez Lvarez J" first="J Emilio" last="Sánchez-Álvarez">J Emilio Sánchez-Álvarez</name><name sortKey="Ya Ez, I Igo" sort="Ya Ez, I Igo" uniqKey="Ya Ez I" first="Í Igo" last="Ya Ez">Í Igo Ya Ez</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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